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Bioactive conformation

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Published by Springer in Berlin, New York .
Written in English


  • Conformational analysis,
  • Molecular Conformation,
  • Binding Sites,
  • Ligands,
  • Nuclear Magnetic Resonance, Biomolecular,
  • Protein Binding,
  • Bioactive compounds -- Analysis,
  • Ligand binding (Biochemistry)

Book details:

Edition Notes

Includes bibliographical references and index.

Statementvolume editor, Thomas Peters ; with contributions by S.V. Evans ... [et al.].
SeriesTopics in current chemistry -- 272-273
ContributionsPeters, T., Evans, S. V. 1959-
LC ClassificationsQD481 .B617 2008
The Physical Object
Pagination2 v. :
ID Numbers
Open LibraryOL22678845M
ISBN 103540490779, 3540490795, 3540490809
ISBN 109783540490777, 9783540490791, 9783540490807
LC Control Number2007942195

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Spatial Screening for the Identification of the Bioactive Conformation of Integrin Ligands. Timo Weide, Armin Modlinger, Horst Kessler. Pages Dynamics and Thermodynamics of Ligand–Protein Interactions. S. W. Homans. From the reviews:"Bioactive Conformation I contains eight chapters on quite different topics within the theme of the series. it will be essential reading for any researcher working in any area that involves binding of a substance to a protein." (T. B. Grindley, Journal of the American Chemical Society, Vol. (2), ) Read more. Modulation of the Bioactive Conformation of Transforming Growth Factor β: Possible Implications of Cation Binding for Biological Function. . Bioactive conformation / [Sergiy E Afonin;] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Book: All Authors / Contributors: Sergiy E Afonin. Find more information about: ISBN: OCLC Number.

NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands Marcel J. J. Blommers, Andre Strauss, Martin Geiser, Paul Ramage, Helmut Sparrer, Wolfgang Jahnke Pages Quantitative Analysis of STD-NMR Spectra of . adshelp[at] The ADS is operated by the Smithsonian Astrophysical Observatory under NASA Cooperative Agreement NNX16AC86A. The Bioactive Conformation of Human Parathyroid Hormone. Structural Evidence for the Extended Helix Postulate. Stephen M. Condon, Isabelle Morize, Shelley Darnbrough, Christopher J. Burns, Bruce E. Miller, Joanne Uhl, Kathleen Burke, Navinchandra Jariwala, Kenneth Locke, Paul H. Krolikowski, N. Vasant Kumar, and ; Richard F. Labaudiniere. We found that, in general, the drug-like molecules present bound to proteins in the Protein Data Bank (PDB) can access easily the bioactive conformation and in fact for 73% of the studied molecules the “bioactive” conformation is within 3kbT from the most stable conformation in solution as determined by DFT/SCRF calculations.

  Locking the dihedral angle of the northern phenyl substituent into the preferred bioactive conformation (Figure 4) was envisaged as a design strategy to improve binding efficiency. As a base case, we assessed conformational freedom of the N3- and C2′-unsubstituted system 22 with relaxed scan, density-functional calculations.[ 30 ]. Bioactive molecules comprise many soluble molecules, including growth factors, angiogenic factors, cytokines, hormones, DNA, siRNA, and immunosuppressant drugs, which interact with and modulate the activity of a cell (Holland and Mikos, ; Kasper and Mikos, ).For instance, early in embryonic development, the fate of the uncommitted cells towards the .   Also, little is available in the areas of bioactive and nutraceutical compounds in bovine and human milks, while books on other mammalian species are non-existent. Bioactive Components in Milk and Dairy Products extensively covers the bioactive components in milk and dairy products of many dairy species, including cows, goats, buffalo, sheep. This unique book also discusses partial structure-functionality (bioactivities) relationships based on conformational studies. This comprehensive work can be used as a handbook to explore potential applications in foods, pharmaceuticals, and .